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A study on the pharmacokinetics in mouse of adenine-9-beta-D-arabinofuranoside 5-monophosphate conjugated with lactosaminated albumin

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Fiume,  L.
Max Planck Institute for Medical Research, Max Planck Society;

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Wieland,  Theodor
Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Fiume, L., Bassi, B., Busi, C., Mattioli, A., & Wieland, T. (1985). A study on the pharmacokinetics in mouse of adenine-9-beta-D-arabinofuranoside 5-monophosphate conjugated with lactosaminated albumin. Experientia: interdisciplinary journal for the life sciences, 41(10), 1326-1328. doi:10.1007/BF01952078.


Cite as: http://hdl.handle.net/21.11116/0000-0005-9963-F
Abstract
In plasma of mice injected with adenine-9-beta-D-arabinofuranoside monophosphate (ara-AMP) coupled to human lactosaminated serum albumin (L-HSA) some of the ara-AMP molecules are enzymatically released, whereas others remain linked to L-HSA. Evidence has been obtained that ara-AMP is not deaminated when it is conjugated to L-HSA, in contrast to the free drug which is rapidly metabolized to its hypoxanthine derivative.