CpG-Loaded Multifunctional Cationic Nanohydrogel Particles as Self-Adjuvanting 
Glycopeptide Antitumor Vaccines

Hartmann, Sebastian; Nuhn, Lutz; Palitzsch, Björn; Glaffig, Markus; Stergiou, Natascha; Gerlitzki, Bastian; Schmitt, Edgar; Kunz, Horst; Zentel, Rudolf

doi:10.1002/adhm.201400460

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CpG-Loaded Multifunctional Cationic Nanohydrogel Particles as Self-Adjuvanting Glycopeptide Antitumor Vaccines

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Citation

Hartmann, S., Nuhn, L., Palitzsch, B., Glaffig, M., Stergiou, N., Gerlitzki, B., et al. (2015). CpG-Loaded Multifunctional Cationic Nanohydrogel Particles as Self-Adjuvanting Glycopeptide Antitumor Vaccines. Advanced Healthcare Materials, 4(4), 522-527. doi:10.1002/adhm.201400460.

Cite as: https://hdl.handle.net/21.11116/0000-0005-9ADA-8

Abstract

Self-adjuvanting antitumor vaccines by multifunctional cationic nanohydrogels loaded with CpG. A conjugate consisting of tumor-associated MUC1-glycopeptide B-cell epitope and tetanus toxin T-cell epitope P2 is linked to cationic nanogels. Oligonucleotide CpG complexation enhances toll-like receptor (TLR) stimulated T-cell proliferation and rapid immune activation. This co-delivery promotes induction of specific MUC1-antibodies binding to human breast tumor cells without external adjuvant.