A Fully Synthetic Glycopeptide Antitumor Vaccine Based on Multiple Antigen 
Presentation on a Hyperbranched Polymer

Glaffig, Markus; Palitzsch, Björn; Hartmann, Sebastian; Schüll, Christoph; Nuhn, Lutz; Gerlitzki, Bastian; Schmitt, Edgar; Frey, Holger; Kunz, Horst

doi:10.1002/chem.201400256

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A Fully Synthetic Glycopeptide Antitumor Vaccine Based on Multiple Antigen Presentation on a Hyperbranched Polymer

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Glaffig, M., Palitzsch, B., Hartmann, S., Schüll, C., Nuhn, L., Gerlitzki, B., et al. (2014). A Fully Synthetic Glycopeptide Antitumor Vaccine Based on Multiple Antigen Presentation on a Hyperbranched Polymer. Chemistry – A European Journal, 20(15), 4232-4236. doi:10.1002/chem.201400256.

Cite as: https://hdl.handle.net/21.11116/0000-0005-9AD4-E

Abstract

Abstract For antitumor vaccines both the selected tumor-associated antigen, as well as the mode of its presentation, affect the immune response. According to the principle of multiple antigen presentation, a tumor-associated MUC1 glycopeptide combined with the immunostimulating T-cell epitope P2 from tetanus toxoid was coupled to a multi-functionalized hyperbranched polyglycerol by “click chemistry”. This globular polymeric carrier has a flexible dendrimer-like structure, which allows optimal antigen presentation to the immune system. The resulting fully synthetic vaccine induced strong immune responses in mice and IgG antibodies recognizing human breast-cancer cells.