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Journal Article

Water-Soluble Polymers Coupled with Glycopeptide Antigens and T-Cell Epitopes as Potential Antitumor Vaccines

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Citation

Nuhn, L., Hartmann, S., Palitzsch, B., Gerlitzki, B., Schmitt, E., Zentel, R., et al. (2013). Water-Soluble Polymers Coupled with Glycopeptide Antigens and T-Cell Epitopes as Potential Antitumor Vaccines. Angewandte Chemie, International Edition, 52(40), 10652-10656. doi:10.1002/anie.201304212.


Cite as: https://hdl.handle.net/21.11116/0000-0005-9ACF-5
Abstract
Highly decorated: Tumor-associated MUC1 glycopeptide and tetanus toxoid T-cell epitope P2 can be attached to water-soluble poly(N-(2-hydroxypropyl)methacrylamide) carriers by orthogonal ligation techniques. Fully synthetic vaccine A with additional nanostructure-promoting domains induced antibodies that exhibit high affinity to tumor cells.