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Self-organization in development, regeneration and organoids.

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Vu,  H. T. K.
Department of Tissue Dynamics and Regeneration, MPI for Biophysical Chemistry, Max Planck Society;

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Rink,  J. C.
Department of Tissue Dynamics and Regeneration, MPI for Biophysical Chemistry, Max Planck Society;

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Citation

Werner, S., Vu, H. T. K., & Rink, J. C. (2017). Self-organization in development, regeneration and organoids. Current Opinion in Cell Biology, 44, 102-109. doi:10.1016/j.ceb.2016.09.002.


Cite as: https://hdl.handle.net/21.11116/0000-0005-A2A5-9
Abstract
Self-organization of cells is a fundamental design principle in biology, yet the inherent non-linearity of self-organizing systems often poses significant challenges in deciphering the underlying mechanisms. Here, we discuss recent progress in this respect, focusing on examples from development, regeneration and organoid differentiation. Together, these three paradigms emphasize the active material properties of tissues that result from the functional coupling between individual cells as active units. Further, we discuss the challenge of obtaining reproducible outcomes on the basis of self-organizing systems, which development and regeneration, but not the current organoid culture protocols, achieve.