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Journal Article

Drying Enhances Signal Intensities for Global GC-MS Metabolomics

MPS-Authors
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Liebeke,  Manuel
Department of Symbiosis, Max Planck Institute for Marine Microbiology, Max Planck Society;

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Puskas,  Erik
Department of Symbiosis, Max Planck Institute for Marine Microbiology, Max Planck Society;

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Fulltext (public)

Liebeke_19_01.pdf
(Publisher version), 797KB

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Citation

Liebeke, M., & Puskas, E. (2019). Drying Enhances Signal Intensities for Global GC-MS Metabolomics. Metabolites, 9(4): 68. doi:10.3390/metabo9040068.


Cite as: http://hdl.handle.net/21.11116/0000-0005-BA24-1
Abstract
We report here that a straightforward change of the standard derivatization procedure for GC-MS metabolomics is leading to a strong increase in metabolite signal intensity. Drying samples between methoxymation and trimethylsilylation significantly increased signals by two- to tenfold in extracts of yeast cells, plant and animal tissue, and human urine. This easy step reduces the cost of sample material and the need for expensive new hardware.