Emergence of human-adapted Salmonella enterica is linked to the Neolithization 
process

Key, Felix Michael; Posth, Cosimo; Esquivel-Gomez, Luis R.; Hübler, Ron; Spyrou, Maria A.; Neumann, Gunnar; Furtwängler, Anja; Sabin, Susanna; Burri, Marta; Wissgott, Antje; Lankapalli, Aditya Kumar; Vågene, Åshild J.; Meyer, Matthias; Nagel, Sarah; Tukhbatova, Rezeda I.; Khokhlov, Aleksandr; Chizhevsky, Andrey; Hansen, Svend; Belinsky, Andrey B.; Kalmykov, Alexey; Kantorovich, Anatoly R.; Maslov, Vladimir E.; Stockhammer, Philipp W.; Vai, Stefania; Zavattaro, Monica; Riga, Alessandro; Caramelli, David; Skeates, Robin; Beckett, Jessica; Gradoli, Maria Giuseppina; Steuri, Noah; Hafner, Albert; Ramstein, Marianne; Siebke, Inga; Lösch, Sandra; Erdal, Yilmaz Selim; Alikhan, Nabil-Fareed; Zhou, Zhemin; Achtman, Mark; Bos, Kirsten I.; Reinhold, Sabine; Haak, Wolfgang; Kühnert , Denise; Herbig, Alexander; Krause, Johannes

doi:10.1038/s41559-020-1106-9

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Emergence of human-adapted Salmonella enterica is linked to the Neolithization process

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Key, Felix Michael
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons188736

Posth, Cosimo
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons127181

Hübler, Ron
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons189338

Spyrou, Maria A.
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons239489

Neumann, Gunnar
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons222907

Sabin, Susanna
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons202987

Burri, Marta
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons59177

Wissgott, Antje
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons217824

Lankapalli, Aditya Kumar
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons203209

Vågene, Åshild J.
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons72846

Meyer, Matthias
Advanced DNA Sequencing Techniques, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

/persons/resource/persons181059

Nagel, Sarah
Advanced DNA Sequencing Techniques, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

/persons/resource/persons222993

Tukhbatova, Rezeda I.
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons207359

Stockhammer, Philipp W.
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons188392

Bos, Kirsten I.
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons186115

Haak, Wolfgang
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons179620

Herbig, Alexander
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons72801

Krause, Johannes
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Citation

Key, F. M., Posth, C., Esquivel-Gomez, L. R., Hübler, R., Spyrou, M. A., Neumann, G., et al. (2020). Emergence of human-adapted Salmonella enterica is linked to the Neolithization process. Nature Ecology & Evolution, 4, 324-333. doi:10.1038/s41559-020-1106-9.

Cite as: https://hdl.handle.net/21.11116/0000-0005-BA1E-9

Abstract

It has been hypothesized that the Neolithic transition towards an agricultural and pastoralist economy facilitated the emergence of human-adapted pathogens. Here, we recovered eight Salmonella enterica subsp. enterica genomes from human skeletons of transitional foragers, pastoralists and agropastoralists in western Eurasia that were up to 6,500 yr old. Despite the high genetic diversity of S. enterica, all ancient bacterial genomes clustered in a single previously uncharacterized branch that contains S. enterica adapted to multiple mammalian species. All ancient bacterial genomes from prehistoric (agro-)pastoralists fall within a part of this branch that also includes the human-specific S. enterica Paratyphi C, illustrating the evolution of a human pathogen over a period of 5,000 yr. Bacterial genomic comparisons suggest that the earlier ancient strains were not host specific, differed in pathogenic potential and experienced convergent pseudogenization that accompanied their downstream host adaptation. These observations support the concept that the emergence of human-adapted S. enterica is linked to human cultural transformations.