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Emergence of human-adapted Salmonella enterica is linked to the Neolithization process

MPG-Autoren
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Key,  Felix M.
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons188736

Posth,  Cosimo
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons221557

Esquivel Gomez,  Luis Roger
tide, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons127181

Hübler,  Ron
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons189338

Spyrou,  Maria A.
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons239489

Neumann,  Gunnar U.
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons222907

Sabin,  Susanna
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons202987

Burri Promerová,  Marta
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons59177

Wissgott,  Antje
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons217824

Lankapalli,  Aditya Kumar
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons203209

Vågene,  Åshild J.
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons222993

Tukhbatova,  Rezeda
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons207359

Stockhammer,  Philipp W.
MHAAM, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons188392

Bos,  Kirsten
CoDisEASe, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons186115

Haak,  Wolfgang
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons221052

Kühnert,  Denise
tide, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons179620

Herbig,  Alexander
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons72801

Krause,  Johannes
MHAAM, Max Planck Institute for the Science of Human History, Max Planck Society;

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Zitation

Key, F. M., Posth, C., Esquivel Gomez, L. R., Hübler, R., Spyrou, M. A., Neumann, G. U., et al. (2020). Emergence of human-adapted Salmonella enterica is linked to the Neolithization process. Nature Ecology & Evolution, 4(3), 324-333. doi:10.1038/s41559-020-1106-9.


Zitierlink: https://hdl.handle.net/21.11116/0000-0005-BEBA-4
Zusammenfassung
It has been hypothesized that the Neolithic transition towards an agricultural and pastoralist economy facilitated the emergence of human-adapted pathogens. Here, we recovered eight Salmonella enterica subsp. enterica genomes from human skeletons of transitional foragers, pastoralists and agropastoralists in western Eurasia that were up to 6,500 yr old. Despite the high genetic diversity of S. enterica, all ancient bacterial genomes clustered in a single previously uncharacterized branch that contains S. enterica adapted to multiple mammalian species. All ancient bacterial genomes from prehistoric (agro-)pastoralists fall within a part of this branch that also includes the human-specific S. enterica Paratyphi C, illustrating the evolution of a human pathogen over a period of 5,000 yr. Bacterial genomic comparisons suggest that the earlier ancient strains were not host specific, differed in pathogenic potential and experienced convergent pseudogenization that accompanied their downstream host adaptation. These observations support the concept that the emergence of human-adapted S. enterica is linked to human cultural transformations.