Fuse or die: Shaping mitochrondrial fate during starvation

Rambold, Angelika; Kostelecky , B.; Lippencott-Schwarz, J.

doi:10.4161/cib.17667

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Fuse or die: Shaping mitochrondrial fate during starvation

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Rambold, Angelika
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306350/
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Citation

Rambold, A., Kostelecky, B., & Lippencott-Schwarz, J. (2011). Fuse or die: Shaping mitochrondrial fate during starvation. Communicative & Integrative Biology, 4, 752-754. doi:10.4161/cib.17667.

Cite as: https://hdl.handle.net/21.11116/0000-0005-C438-F

Abstract

Mitochondria continuously change their shape and thereby influence different cellular processes like cell death or development. Recently, we showed that during starvation mitochondria fuse into a highly connected network. The change in mitochondrial shape was dependent on inactivation of the fission protein Drp1, through targeting of two different phosphorylation sites. This rapid inhibition of mitochondrial fission led to unopposed fusion, protecting mitochondria from starvation-induced degradation and enabling the cell to survive nutrient scarce conditions.