Selective and Reversible Reduction of Odor Sensitivity in the Rat by 
Concanavalin A

Apfelbach, R; Weiler, E; Asselbergs, WF; Polak, EH; Slotnick, B

doi:10.1016/S0031-9384(98)00197-8

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Selective and Reversible Reduction of Odor Sensitivity in the Rat by Concanavalin A

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https://www.sciencedirect.com/science/article/pii/S0031938498001978
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Citation

Apfelbach, R., Weiler, E., Asselbergs, W., Polak, E., & Slotnick, B. (1998). Selective and Reversible Reduction of Odor Sensitivity in the Rat by Concanavalin A. Physiology & Behavior, 65(3), 513-516. doi:10.1016/S0031-9384(98)00197-8.

Cite as: http://hdl.handle.net/21.11116/0000-0005-C769-5

Abstract

Rats were trained using an olfactometer to detect low concentrations of ethyl acetate (EA) or dimethyl disulphide vapor (DMDS). Concanavalin A (ConA) applied to the olfactory mucosa had no effect on ability of rats to detect low concentrations of EA but produced a marked deficit in detection in DMDS. DMDS detection performance returned to control levels 3 days after the ConA treatment. These results provide the first behavioral evidence for odor-specific inhibition by chemical modification of the olfactory epithelium and support the notion that ConA selectively inactivates one or more types (subclasses) of olfactory receptor proteins.