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Journal Article

Identity domains capture individual differences from across the behavioral repertoire

MPS-Authors

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Forkosh, Oren
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Karamihalev, Stoyo
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Roeh, Simone
AG Binder, Elisabeth, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society;
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

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Anpilov, Sergey
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Touma, Chadi
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Nussbaumer, Markus
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;
AG Landgraf, Rainer, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society;

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Flachskamm, Cornelia
AG Kimura, Mayumi, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society;

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Kaplick, Paul M.
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Shemesh, Yair
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Chen, Alon
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Citation

Forkosh, O., Karamihalev, S., Roeh, S., Alon, U., Anpilov, S., Touma, C., et al. (2019). Identity domains capture individual differences from across the behavioral repertoire. Nature Neuroscience, 22(12), 2023-+. doi:10.1038/s41593-019-0516-y.

Abstract

Personality traits can offer considerable insight into the biological basis of individual differences. However, existing approaches toward understanding personality across species rely on subjective criteria and limited sets of behavioral readouts, which result in noisy and often inconsistent outcomes. Here we introduce a mathematical framework for describing individual differences along dimensions with maximum consistency and discriminative power. We validate this framework in mice, using data from a system for high-throughput longitudinal monitoring of group-housed male mice that yields a variety of readouts from across the behavioral repertoire of individual animals. We demonstrate a set of stable traits that capture variability in behavior and gene expression in the brain, allowing for better-informed mechanistic investigations into the biology of individual differences.