Visualizing cortical response to optogenetic stimulation and sensory inputs 
using multispectral handheld optoacoustic imaging

Ovsepian, SV; Jiang, Y; Sardella, TCP; Malekzadeh-Najafabadi , J; Burton, NC; Yu, X; Ntziachristos , V

doi:10.1016/j.pacs.2019.100153

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Visualizing cortical response to optogenetic stimulation and sensory inputs using multispectral handheld optoacoustic imaging

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Yu, X
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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https://www.sciencedirect.com/science/article/pii/S221359791930076X
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Citation

Ovsepian, S., Jiang, Y., Sardella, T., Malekzadeh-Najafabadi, J., Burton, N., Yu, X., et al. (2020). Visualizing cortical response to optogenetic stimulation and sensory inputs using multispectral handheld optoacoustic imaging. Photoacoustics, 17: 100153, pp. 1-4. doi:10.1016/j.pacs.2019.100153.

Cite as: https://hdl.handle.net/21.11116/0000-0005-DB6F-9

Abstract

To date, the vast majority of intra-vital neuroimaging systems applied in clinic and diagnostics is stationary with a rigid scanning element, requires specialized facilities and costly infrastructure. Here, we describe a simple yet radical approach for optoacoustic (photoacoustic) brain imaging in vivo using a light-weight handheld probe. It enables multispectral video-rate visualization of hemoglobin gradient changes in the cortex of adult rats induced by whisker and forelimb sensory inputs, as well as by optogenetic stimulation of intra-cortical connections. With superb penetration and molecular specificity, described here in method holds major promises for future applications in research, routine ambulatory neuroimaging, and diagnostics.