English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Journal Article

Opacity determinants of Neisseria gonorrhoeae: gene expression and chromosomal linkage to the gonococcal pilus gene

MPS-Authors
/persons/resource/persons246110

Stern,  Anne
Max Planck Institute for Medical Research, Max Planck Society;

/persons/resource/persons246112

Nickel,  Peter
Max Planck Institute for Medical Research, Max Planck Society;

/persons/resource/persons82047

Meyer,  Thomas F.
Max Planck Institute for Medical Research, Max Planck Society;

External Resource

https://www.cell.com/action/showPdf?pii=0092-8674%2884%2990375-1
(Any fulltext)

https://doi.org/10.1016/0092-8674(84)90375-1
(Any fulltext)

Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Stern, A., Nickel, P., Meyer, T. F., & So, M. (1984). Opacity determinants of Neisseria gonorrhoeae: gene expression and chromosomal linkage to the gonococcal pilus gene. Cell, 37(2), 447-456. doi:10.1016/0092-8674(84)90375-1.


Cite as: https://hdl.handle.net/21.11116/0000-0005-E13F-7
Abstract
In N. gonorrhoeae, the expression of pilus and opacity (Op) proteins can be switched on and off and a single cell apparently has a whole repertoire of genes to express many serologically distinguishable protein types. We describe the isolation of several different Op genes and of nonexpressing gene equivalents, all derived from isogenic gonococcal variants. In the E. coli host, Op proteins identical with those made in the respective N. gonorrhoeae strain are produced. The Op genes map near the pilus expression locus. Genomic blotting experiments with an Op gene probe reveal complex hybridization patterns but little heterogeneity among the genes of Op variants. It appears that colonial variation involving the Op protein of N. gonorrhoeae is based on minor sequence alterations, in contrast to the pilus variation system, in which changes in the expression can be evoked by substantial genomic rearrangements.