Help Privacy Policy Disclaimer
  Advanced SearchBrowse




Journal Article

Critical steps of Plasmodium falciparum ookinete maturation


Valleriani,  Angelo
Angelo Valleriani, Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

External Resource
No external resources are shared
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)

(Supplementary material), 3MB


Siciliano, G., Costa, G., Suárez-Cortés, P., Valleriani, A., Alano, P., & Levashina, E. A. (2020). Critical steps of Plasmodium falciparum ookinete maturation. Frontiers in Microbiology, 11: 269. doi:10.3389/fmicb.2020.00269.

Cite as: http://hdl.handle.net/21.11116/0000-0005-E519-D
The egress and fertilization of Plasmodium gametes and development of a motile ookinete are the first crucial steps that mediate the successful transmission of the malaria parasites from humans to the Anopheles vector. However, limited information exists about the cell biology and regulation of this process. Technical impediments in the establishment of in vitro conditions for ookinete maturation in Plasmodium falciparum and other human malaria parasites further constrain a detailed characterization of ookinete maturation. Here, using fluorescence microscopy and immunolabeling, we compared P. falciparum ookinete maturation in Anopheles coluzzii mosquitoes in vivo and in cell culture in vitro. Our results identified two critical steps in ookinete maturation that are regulated by distinct mosquito factors, thereby highlighting the role of the mosquito environment in the transmission efficiency of malaria parasites.