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Fabrication of glyco-metal-organic frameworks for targeted interventional photodynamic/chemotherapy for hepatocellular carcinoma through percutaneous transperitoneal puncture

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Seeberger,  Peter H.
Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Citation

Hu, J., Wu, W., Qin, Y., Liu, C., Wei, P., Hu, J., et al. (2020). Fabrication of glyco-metal-organic frameworks for targeted interventional photodynamic/chemotherapy for hepatocellular carcinoma through percutaneous transperitoneal puncture. Advanced Functional Materials, 30(19): 1910084. doi:10.1002/adfm.201910084.


Cite as: http://hdl.handle.net/21.11116/0000-0005-EB33-9
Abstract
Abstract Hepatocellular carcinoma (HCC) causes high morbidity and mortality due to a lack of adequate treatments. Cancer treatments have benefited from nanotechnology approaches that integrate multimodal synergistic therapies. A synergistic, minimally invasive strategy of interventional photodynamic therapy (IPDT) and chemotherapy for HCC treatment through percutaneous transperitoneal puncture is disclosed that is based on photosensitive porphyrinic galactose-modified metal-organic frameworks (PCN-224) first used as hepatic targeting and encapsulated with anticancer drug doxorubicin (DOX@Gal-PCN-224). Real-time imaging reveals the effective accumulation of the integrated nanosystem in the HCC cells and tumor tissues due to hepatic targeting. Evaluation of the anti-tumor efficiency of this nanosystem on orthotopic transplantation tumors with the aid of minimally invasive intervention shows a tumor inhibition rate of 98%. The synergistic effects induce high-level cell apoptosis and tissue necrosis in vitro and in vivo. This bimodal IPDT/chemotherapy strategy holds great potential in the clinical treatment for HCC.