A ratiometric 19F MR-based method for the quantification of Ca2+ using 
responsive paramagnetic probes

Gambino, G; Gambino, T; Pohmann, R; Angelovski, G

doi:10.1039/C9CC09977H

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A ratiometric 19F MR-based method for the quantification of Ca2+ using responsive paramagnetic probes

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Gambino, G
Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Gambino, T
Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Pohmann, R
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Angelovski, G
Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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https://pubs.rsc.org/en/content/articlepdf/2020/cc/c9cc09977h
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Citation

Gambino, G., Gambino, T., Pohmann, R., & Angelovski, G. (2020). A ratiometric 19F MR-based method for the quantification of Ca2+ using responsive paramagnetic probes. Chemical Communications, 56(24), 3492-3495. doi:10.1039/C9CC09977H.

Cite as: https://hdl.handle.net/21.11116/0000-0005-FC9B-1

Abstract

We present a method for assessing the extracellular calcium concentration using 19F chemical shift imaging. Specifically, a custom made calcium-responsive and lanthanide-based 19F MRI probe that undergoes a strong and highly specific modulation of its signal upon coordination with calcium ions was developed and its performance is presented.