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Journal Article

Prospects of third-generation femtosecond laser technology in biological spectromicroscopy

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Fattahi, H., Fattahi, Z., & Ghorbani, A. (2018). Prospects of third-generation femtosecond laser technology in biological spectromicroscopy. Journal of Optics, 20(5): 054005. doi:10.1088/2040-8986/aab79a.

Cite as: https://hdl.handle.net/21.11116/0000-0006-0049-8
The next generation of biological imaging modalities will be a movement towards super-resolution, label-free approaches to realize subcellular images in a nonperturbative, non-invasive manner and towards new detection metrologies to reach a higher sensitivity and dynamic range. In this paper, we discuss how the third generation femtosecond laser technology in combination with the already existing concepts in time-resolved spectroscopy could fulfill the requirements of these exciting prospects. The expected enhanced specificity and sensitivity of the envisioned super-resolution microscope could lead us to a better understanding of the inter- and intra-cellular molecular transport and DNA-protein interaction.