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Ketamine-xylazine anaesthesia blocks consolidation of ocular dominance changes in kitten visual cortex

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Rauschecker,  JP
Former Department Structure and Function of Natural Nerve-Net , Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Hahn,  S
Former Department Structure and Function of Natural Nerve-Net , Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Rauschecker, J., & Hahn, S. (1987). Ketamine-xylazine anaesthesia blocks consolidation of ocular dominance changes in kitten visual cortex. Nature, 326(6109), 183-185. doi:10.1038/326183a0.


Cite as: http://hdl.handle.net/21.11116/0000-0006-02E8-2
Abstract
In the visual cortex of mammals, response properties of single neurons can be changed by restricted visual experience during early postnatal development1. Covering one eye for four to eight hours when kittens are at the peak of the sensitive period is sufficient to weaken the influence of the occluded eye on cortical neurons resulting in a noticeable shift of ocular dominance towards the open eye2–5. The underlying changes in synaptic connections do not occur so readily when a kitten is anaesthetized and paralysed6–8. We report here that an ocular dominance shift is prevented in alert kittens that receive repeated brief monocular exposures when these are followed by ketamine–xylazine anaesthesia. This retrograde effect on cortical plasticity suggests that the process by which synaptic activity is converted into structural changes has been disturbed.