Rolling ES cells down the Waddington landscape with Oct4 and Sox2

Iovino, Nicola; Cavalli, Giacomo

doi:10.1016/j.cell.2011.05.027

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Rolling ES cells down the Waddington landscape with Oct4 and Sox2

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Iovino, Nicola
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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https://www.sciencedirect.com/science/article/pii/S0092867411005885?via%3Dihub
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Citation

Iovino, N., & Cavalli, G. (2011). Rolling ES cells down the Waddington landscape with Oct4 and Sox2. Cell, 145, 815-817. doi:10.1016/j.cell.2011.05.027.

Cite as: https://hdl.handle.net/21.11116/0000-0006-0787-A

Abstract

Embryonic stem cell (ESC) pluripotency is maintained by core transcriptional circuits whereby critical factors sustain their own expression while preventing the expression of genes required for differentiation. Thomson et al. (2011) now show that two core components of the pluripotency circuit, Oct4 and Sox2, are also critical for germ layer fate choice.