English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Larval zebrafish proteome regulation in response to an environmental challenge

MPS-Authors
/persons/resource/persons239589

Langebeck-Jensen,  Kaspar
Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society;

/persons/resource/persons239591

Shahar,  Or D.
Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society;

/persons/resource/persons208206

Schuman,  Erin M.
Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society;

/persons/resource/persons137770

Langer,  Julian D.
Proteomics and Mass Spectrometry, Max Planck Institute of Biophysics, Max Planck Society;

External Resource
No external resources are shared
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Langebeck-Jensen, K., Shahar, O. D., Schuman, E. M., Langer, J. D., & Ryu, S. (2019). Larval zebrafish proteome regulation in response to an environmental challenge. Proteomics, 19. doi:10.1002/pmic.201900028.


Cite as: http://hdl.handle.net/21.11116/0000-0007-E068-7
Abstract
Adaptation to the environment during development influences the life‐long survival of an animal. While brain‐wide proteomic changes are expected to underlie such experience‐driven physiological and behavioral flexibility, a comprehensive overview of the nature and extent of the proteomic regulation following an environmental challenge during development is currently lacking. In this study, the brain proteome of larval zebrafish is identified and it is determined how it is altered by an exposure to a natural and physical environmental challenge, namely prolonged exposure to strong water currents. A comprehensive larval zebrafish brain proteome is presented here. Furthermore, 57 proteins that are regulated by the exposure to an environmental challenge are identified, which cover multiple functions including neuronal plasticity, the stress response, axonal growth and guidance, spatial learning, and energy metabolism. These represent candidate proteins that may play crucial roles for the adaption to an environmental challenge during development.