Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and 
survival

Song, Jian; Lokmic, Zerina; Lämmermann, Tim; Rolf, Julia; Wu, Chuan; Zhang, Xueli; Hallmann, Rupert; Hannocks, Melanie-Jane; Horn, Nathalie; Ruegg, Markus A.; Sonnenberg, Arnoud; Georges-Labouesse, Elisabeth; Winkler, Thomas H.; Kearney, John F.; Cardell, Susanna; Sorokin, and Lydia

doi:10.1073/pnas.1218131110

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Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival

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Lämmermann, Tim
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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https://www.pnas.org/content/110/31/E2915.long
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Citation

Song, J., Lokmic, Z., Lämmermann, T., Rolf, J., Wu, C., Zhang, X., et al. (2013). Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival. Proceedings of the National Academy of Sciences of the United States of America, 110, E2915-E2924. doi:10.1073/pnas.1218131110.

Cite as: https://hdl.handle.net/21.11116/0000-0006-0C4D-8

Abstract

We describe a unique extracellular matrix (ECM) niche in the spleen, the marginal zone (MZ), characterized by the basement membrane glycoproteins, laminin α5 and agrin, that promotes formation of a specialized population of MZ B lymphocytes that respond rapidly to blood-borne antigens. Mice with reduced laminin α5 expression show reduced MZ B cells and increased numbers of newly formed (NF) transitional B cells that migrate from the bone marrow, without changes in other immune or stromal cell compartments. Transient integrin α6β1-mediated interaction of NF B cells with laminin α5 in the MZ supports the MZ B-cell population, their long-term survival, and antibody response. Data suggest that the unique 3D structure and biochemical composition of the ECM of lymphoid organs impacts on immune cell fate.