English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Mapping short association fibers in the early cortical visual processing stream using in vivo diffusion tractography

MPS-Authors
/persons/resource/persons199444

Attar,  Fakhereh Movahedian
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons180061

Kirilina,  Evgeniya
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Center for Cognitive Neuroscience Berlin (CCNB), FU Berlin, Germany;

/persons/resource/persons241055

Haenelt,  Daniel
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons188645

Pine,  Kerrin
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons20053

Trampel,  Robert
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons189347

Edwards,  Luke
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons147461

Weiskopf,  Nikolaus
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Felix Bloch Institute for Solid State Physics, University of Leipzig, Germany;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)

Attar_2020.pdf
(Publisher version), 4MB

Supplementary Material (public)
There is no public supplementary material available
Citation

Attar, F. M., Kirilina, E., Haenelt, D., Pine, K., Trampel, R., Edwards, L., et al. (2020). Mapping short association fibers in the early cortical visual processing stream using in vivo diffusion tractography. Cerebral Cortex, 30(8), 4496-4514. doi:10.1093/cercor/bhaa049.


Cite as: http://hdl.handle.net/21.11116/0000-0006-4707-3
Abstract
Short association fibers (U-fibers) connect proximal cortical areas and constitute the majority of white matter connections in the human brain. U-fibers play an important role in brain development, function, and pathology but are underrepresented in current descriptions of the human brain connectome, primarily due to methodological challenges in diffusion magnetic resonance imaging (dMRI) of these fibers. High spatial resolution and dedicated fiber and tractography models are required to reliably map the U-fibers. Moreover, limited quantitative knowledge of their geometry and distribution makes validation of U-fiber tractography challenging. Submillimeter resolution diffusion MRI-facilitated by a cutting-edge MRI scanner with 300 mT/m maximum gradient amplitude-was used to map U-fiber connectivity between primary and secondary visual cortical areas (V1 and V2, respectively) in vivo. V1 and V2 retinotopic maps were obtained using functional MRI at 7T. The mapped V1-V2 connectivity was retinotopically organized, demonstrating higher connectivity for retinotopically corresponding areas in V1 and V2 as expected. The results were highly reproducible, as demonstrated by repeated measurements in the same participants and by an independent replication group study. This study demonstrates a robust U-fiber connectivity mapping in vivo and is an important step toward construction of a more complete human brain connectome.