When Hexokinase Gets that NAG-ing Feeling

O'Sullivan, David; Kelly, Beth; Pearce, Erika L.

doi:org/10.1016/j.cmet.2016.07.021

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When Hexokinase Gets that NAG-ing Feeling

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O'Sullivan, David
Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Kelly, Beth
Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Pearce, Erika L.
Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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https://www.sciencedirect.com/science/article/pii/S1550413116303692?via%3Dihub
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Citation

O'Sullivan, D., Kelly, B., & Pearce, E. L. (2016). When Hexokinase Gets that NAG-ing Feeling. Cell Metabolism, 24, 198-200. doi:org/10.1016/j.cmet.2016.07.021.

Cite as: https://hdl.handle.net/21.11116/0000-0006-4901-7

Abstract

Immune cell recognition of bacterial products usually occurs via specific pattern recognition receptors, but new research recently published in Cell by Wolf et al. (2016) demonstrates that the glycolytic enzyme hexokinase can act as an innate immune sensor by binding to bacterial derived N-acetylglucosamine (NAG).