English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Memory CD8+ T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development

MPS-Authors
/persons/resource/persons201374

O'Sullivan,  David
Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

/persons/resource/persons201435

Pearce,  Edward J.
Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

/persons/resource/persons201431

Pearce,  Erika L.
Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)

O Sullivan et al..pdf
(Publisher version), 3MB

Supplementary Material (public)
There is no public supplementary material available
Citation

O'Sullivan, D., van der Windt, G. J., Huang, S.-C.-C., Curtis, J., Chang, C.-H., Buck, M. D., et al. (2014). Memory CD8+ T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development. Immunity, 41, 75-88. doi:org/10.1016/j.immuni.2014.06.005.


Cite as: https://hdl.handle.net/21.11116/0000-0006-542A-D
Abstract
Generation of CD8+ memory T cells requires metabolic reprogramming that is characterized by enhanced mitochondrial fatty-acid oxidation (FAO). However, where the fatty acids (FA) that fuel this process come from remains unclear. While CD8+ memory T cells engage FAO to a greater extent, we found that they acquired substantially fewer long-chain FA from their external environment than CD8+ effector T (Teff) cells. Rather than using extracellular FA directly, memory T cells used extracellular glucose to support FAO and oxidative phosphorylation (OXPHOS), suggesting that lipids must be synthesized to generate the substrates needed for FAO. We have demonstrated that memory T cells rely on cell intrinsic expression of the lysosomal hydrolase LAL (lysosomal acid lipase) to mobilize FA for FAO and memory T cell development. Our observations link LAL to metabolic reprogramming in lymphocytes and show that cell intrinsic lipolysis is deterministic for memory T cell fate.