Europium(III) Macrocyclic Chelates Appended with Tyrosine-based Chromophores 
and Di-(2-picolyl)amine-based Receptors: Turn-On Luminescent Chemosensors 
Selective to Zinc(II) Ions

Wang, G; Platas-Iglesias, C; Angelovski, G

doi:10.1002/cplu.201900731

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Europium(III) Macrocyclic Chelates Appended with Tyrosine-based Chromophores and Di-(2-picolyl)amine-based Receptors: Turn-On Luminescent Chemosensors Selective to Zinc(II) Ions

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Wang, G
Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Angelovski, G
Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/cplu.201900731
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Citation

Wang, G., Platas-Iglesias, C., & Angelovski, G. (2020). Europium(III) Macrocyclic Chelates Appended with Tyrosine-based Chromophores and Di-(2-picolyl)amine-based Receptors: Turn-On Luminescent Chemosensors Selective to Zinc(II) Ions. ChemPlusChem, 85(5), 806-814. doi:10.1002/cplu.201900731.

Cite as: https://hdl.handle.net/21.11116/0000-0006-56D4-A

Abstract

Zinc ions play an important role in many biological processes in the human body. To selectively detect Zn2+, two EuDO3A‐based complexes (DO3A=1,4,7,10‐tetraazacyclododecane‐1,4,7‐tricarboxylic acid) appended with tyrosine as a chromophore and di‐(2‐picolyl)amine (DPA) as the Zn2+ recognition moiety were developed as suitable luminescent sensors. Their luminescence intensity is affected by the photoinduced electron transfer mechanism. Upon addition of Zn2+, both probes display an up to sevenfold enhancement in Eu3+ emission. Competition experiments demonstrated their specificity toward Zn2+ over other metal ions, while also revealing the nonspecificity of the derivatives lacking the DPA‐moiety, thus confirming the essential role of the DPA for the recognition of Zn2+. The induced emission changes of Eu3+ allow for precise quantitative analysis of Zn2+, establishing these lanthanide‐based complexes as viable chemosensors for biological applications.