Help Privacy Policy Disclaimer
  Advanced SearchBrowse




Journal Article

Peptide-induced biomineralization of tin oxide (SnO2) nanoparticles for antibacterial applications


Jahnke,  Timotheus
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available

Singh, A. V., Jahnke, T., Yang, X., Wang, S., Yu, Y., David, H., et al. (2019). Peptide-induced biomineralization of tin oxide (SnO2) nanoparticles for antibacterial applications. Journal of Nanoscience and Nanotechnology, 19(9), 5674-5686. doi:10.1166/jnn.2019.16645.

Cite as: https://hdl.handle.net/21.11116/0000-0006-63E9-4
Recently, there has been growing attention and effort to search for new microbicidal drugs which present different mode of action from those already existing, as an alternative to the global threat of fungal and bacterial multi drug resistance (MDR). Here we propose biological synthesis of SnO2 nanoparticles using mammalian cells as an economic and ecofriendly platform. This presents a novel biogenic method for SnO2 synthesis using metal binding peptides extracted from MCF-7 human cancer cells, which induces the biomineralization of SnO2 nanoparticles. A series of electron donor functional groups and metal binding sites in these peptides reacts with Sn2+ ions and directs the growth of SnO2 nanoparticles without addition of toxic redox and capping agents in the reaction system. Since peptides present reactive sites in aqueous solution at room temperature, a facile reaction environment can be easily achieved. Furthermore, by tuning the reactants' concentration and pH, the size, shape and 3D-structures of SnO2 nanoparticles can be controlled. Peptides also ensure biocompatibility, and SnO2 nanoparticles provide antibacterial properties, which broadens their applications in biomedical fields.