English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  DetailsSummary

Released
Journal Article

Automated glycan assembly in a variable-bed flow reactor provides insights into oligosaccharide–resin interactions

MPS-Authors
/persons/resource/persons242896

Sletten,  Eric T.
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons213288

Danglad-Flores,  José Angél
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons121849

Seeberger,  Peter H.
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)

Article.pdf
(Publisher version), 2MB

Supplementary Material (public)
There is no public supplementary material available
Citation

Sletten, E. T., Danglad-Flores, J. A., Nuño, M., Guthrie, D., & Seeberger, P. H. (2020). Automated glycan assembly in a variable-bed flow reactor provides insights into oligosaccharide–resin interactions. Organic Letters, 22(11), 4213-4216. doi:10.1021/acs.orglett.0c01264.


Cite as: https://hdl.handle.net/21.11116/0000-0006-6C71-2
Abstract
A pressure-based variable-bed flow reactor built for peptide synthesis and capable of real-time monitoring of resin swelling was adapted for automated glycan assembly. In the context of the solid-phase synthesis of several oligosaccharides, the coupling efficiencies, resin growth patterns, and saccharide solvation during the synthesis were determined. The presented work provides the first estimation of on-resin oligosaccharide solvation and an alternative technique to UV–vis monitoring.