English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Analysis of shared common genetic risk between amyotrophic lateral sclerosis and epilepsy

MPS-Authors
There are no MPG-Authors available
External Ressource
No external resources are shared
Supplementary Material (public)

1-s2.0-S0197458020301305-mmc1.docx
(Supplementary material), 4MB

Citation

Schijven, D., Stevelink, R., McCormack, M., van Rheenen, W., Luykx, J. J., Koeleman, B. P., et al. (2020). Analysis of shared common genetic risk between amyotrophic lateral sclerosis and epilepsy. Neurobiology of Aging, 92, 153.e1-153.e5. doi:10.1016/j.neurobiolaging.2020.04.011.


Cite as: http://hdl.handle.net/21.11116/0000-0006-6BDE-9
Abstract
Because hyper-excitability has been shown to be a shared pathophysiological mechanism, we used the latest and largest genome-wide studies in amyotrophic lateral sclerosis (n = 36,052) and epilepsy (n = 38,349) to determine genetic overlap between these conditions. First, we showed no significant genetic correlation, also when binned on minor allele frequency. Second, we confirmed the absence of polygenic overlap using genomic risk score analysis. Finally, we did not identify pleiotropic variants in meta-analyses of the 2 diseases. Our findings indicate that amyotrophic lateral sclerosis and epilepsy do not share common genetic risk, showing that hyper-excitability in both disorders has distinct origins.