STAT3-dependent analysis reveals PDK4 as independent predictor of recurrence in 
prostate cancer

Oberhuber, Monika; Pecoraro, Matteo; Rusz, Mate; Oberhuber, Georg; Wieselberg, Maritta; Haslinger, Peter; Gurnhofer, Elisabeth; Schlederer, Michaela; Limberger, Tanja; Lagger, Sabine; Pencik, Jan; Kodajova, Petra; Högler, Sandra; Stockmaier, Georg; Grund-Gröschke, Sandra; Aberger, Fritz; Bolis, Marco; Theurillat, Jean-Philippe; Wiebringhaus, Robert; Weiss, Theresa; Haitel, Andrea; Brehme, Marc; Wadsak, Wolfgang; Griss, Johannes; Mohr, Thomas; Hofer, Alexandra; Jäger, Anton; Pollheimer, Juergen; Egger, Gerda; Koellensperger, Gunda; Mann, Matthias; Hantusch, Brigitte; Kenner, Lukas

doi:10.15252/msb.20199247

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STAT3-dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer

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Pecoraro, Matteo
Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society;

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Mann, Matthias
Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society;

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引用

Oberhuber, M., Pecoraro, M., Rusz, M., Oberhuber, G., Wieselberg, M., Haslinger, P., Gurnhofer, E., Schlederer, M., Limberger, T., Lagger, S., Pencik, J., Kodajova, P., Högler, S., Stockmaier, G., Grund-Gröschke, S., Aberger, F., Bolis, M., Theurillat, J.-P., Wiebringhaus, R., Weiss, T., Haitel, A., Brehme, M., Wadsak, W., Griss, J., Mohr, T., Hofer, A., Jäger, A., Pollheimer, J., Egger, G., Koellensperger, G., Mann, M., Hantusch, B., & Kenner, L. (2020). STAT3-dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer. MOLECULAR SYSTEMS BIOLOGY, 16(4):. doi:10.15252/msb.20199247.

引用: https://hdl.handle.net/21.11116/0000-0006-72F2-8

要旨

Prostate cancer (PCa) has a broad spectrum of clinical behavior; hence, biomarkers are urgently needed for risk stratification. Here, we aim to find potential biomarkers for risk stratification, by utilizing a gene co-expression network of transcriptomics data in addition to laser-microdissected proteomics from human and murine prostate FFPE samples. We show up-regulation of oxidative phosphorylation (OXPHOS) in PCa on the transcriptomic level and up-regulation of the TCA cycle/OXPHOS on the proteomic level, which is inversely correlated to STAT3 expression. We hereby identify gene expression of pyruvate dehydrogenase kinase 4 (PDK4), a key regulator of the TCA cycle, as a promising independent prognostic marker in PCa. PDK4 predicts disease recurrence independent of diagnostic risk factors such as grading, staging, and PSA level. Therefore, low PDK4 is a promising marker for PCa with dismal prognosis.