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Journal Article

Calcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple Sclerosis.

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Naumann,  Ronald
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Witte, M. E., Schumacher, A.-M., Mahler, C. F., Bewersdorf, J., Lehmitz, J., Scheiter, A., et al. (2019). Calcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple Sclerosis. Neuron, 101(4), 615-624. doi:10.1016/j.neuron.2018.12.023.


Cite as: https://hdl.handle.net/21.11116/0000-0006-7D4A-C
Abstract
Axon loss determines persistent disability in multiple sclerosis patients. Here, we use in vivo calcium imaging in a multiple sclerosis model to show that cytoplasmic calcium levels determine the choice between axon loss and survival. We rule out the endoplasmic reticulum, glutamate excitotoxicity, and the reversal of the sodium-calcium exchanger as sources of intra-axonal calcium accumulation and instead identify nanoscale ruptures of the axonal plasma membrane as the critical path of calcium entry.