Pivoting of microtubules driven by minus-end-directed motors leads to spindle 
assembly.

Winters, Lora; Ban, Ivana; Prelogović, Marcel; Kalinina, Iana M.; Pavin, Nenad; Tolić, Iva M

doi:10.1186/s12915-019-0656-2

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Pivoting of microtubules driven by minus-end-directed motors leads to spindle assembly.

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Winters, Lora
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Kalinina, Iana M.
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Pavin, Nenad
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Tolić, Iva M
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Winters, L., Ban, I., Prelogović, M., Kalinina, I. M., Pavin, N., & Tolić, I. M. (2019). Pivoting of microtubules driven by minus-end-directed motors leads to spindle assembly. BMC biology, 17(1): 42. doi:10.1186/s12915-019-0656-2.

Cite as: https://hdl.handle.net/21.11116/0000-0006-7E02-B

Abstract

At the beginning of mitosis, the cell forms a spindle made of microtubules and associated proteins to segregate chromosomes. An important part of spindle architecture is a set of antiparallel microtubule bundles connecting the spindle poles. A key question is how microtubules extending at arbitrary angles form an antiparallel interpolar bundle.