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Collective cell migration: general themes and new paradigms

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Norden,  Caren
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Lecaudey,  Virginie
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Norden, C., & Lecaudey, V. (2019). Collective cell migration: general themes and new paradigms. Current opinion in genetics & development, 57, 54-60. doi:10.1016/j.gde.2019.06.013.


Cite as: https://hdl.handle.net/21.11116/0000-0006-7F20-8
Abstract
Collective cell migration plays essential roles in embryogenesis and also contributes to disease states. Recent years have seen immense progress in understanding mechanisms and overarching concepts of collective cell migration. Self-organization of moving groups emerges as an important common feature. This includes self-generating gradients, internal chemotaxis or mechanotaxis and contact-dependent polarization within migrating cell groups. Here, we will discuss these concepts and their applications to classical models of collective cell migration. Further, we discuss new models and paradigms of collective cell migration and elaborate on open questions and future challenges. Answering these questions will help to expand our appreciation of this exciting theme in developmental cell biology and contribute to the understanding of disease states.