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Journal Article

Phalloidin depletes the mitochondrial Ca2+ compartment of hepatocytes


Faulstich,  Heinz
Department of Molecular Cell Research, Max Planck Institute for Medical Research, Max Planck Society;

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Faulstich, H., Münter, K., & Mayer, D. (1984). Phalloidin depletes the mitochondrial Ca2+ compartment of hepatocytes. FEBS Letters, 167(2), 241-244. doi:10.1016/0014-5793(84)80134-9.

Cite as: https://hdl.handle.net/21.11116/0000-0006-8ADF-4
In 3 h of incubation, primary cultures of rat hepatocytes attach to the substratum and exchange about 2.2 nmol 45Ca2+ per mg protein. In the presence of 1 μM phalloidin, the exchanged amount of 45Ca2+ was found to be decreased by about 30%. Using the uncoupling agent FCCP and the ionophore A23187 for further characterisation we determined that the 45Ca2+ deficit caused by phalloidin occurs in the FCCP‐sensitive compartment, i.e., the mitochondria.