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Journal Article

Dependence on membrane lipids of the effect of vanadate on calcium and ATP binding to sarcoplasmic reticulum ATPase

MPS-Authors
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Medda,  Pankaj
Max Planck Institute for Medical Research, Max Planck Society;

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Hasselbach,  Wilhelm
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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https://www.degruyter.com/downloadpdf/journals/znc/39/11-12/article-p1137.xml
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https://doi.org/10.1515/znc-1984-11-1224
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Citation

Medda, P., & Hasselbach, W. (1984). Dependence on membrane lipids of the effect of vanadate on calcium and ATP binding to sarcoplasmic reticulum ATPase. Zeitschrift für Naturforschung, C: Journal of Biosciences, 39(11-12), 1137-1140. doi:10.1515/znc-1984-11-1224.


Cite as: https://hdl.handle.net/21.11116/0000-0006-8BB2-4
Abstract
The affinity of the sarcoplasmic reticulum transport ATPase for calcium and ATP is not affected by lipid deprivation while vanadate binding is completely abolished. Lipid substitution restores vanadate binding as well as the vanadate induced disappearance of the enzyme's high affinity calcium and nucleotide binding sites. Nucleotide binding is simultaneously restored with the displacement of vanadate from the enzyme following the occupation of its low affinity calcium binding sites.