High cytotoxicity and membrane permeability of Et3Pb+ in mammalian and plant 
cells

Stournaras, Christos; Faulstich, Heinz; Weber , G.; Zimmermann, H.‐P.; Doenges, K. H.

doi:10.1002/cbf.290020406

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High cytotoxicity and membrane permeability of Et3Pb+ in mammalian and plant cells

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Stournaras, Christos
Max Planck Institute for Medical Research, Max Planck Society;

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Faulstich, Heinz
Department of Molecular Cell Research, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Stournaras, C., Faulstich, H., Weber, G., Zimmermann, H., & Doenges, K. H. (1984). High cytotoxicity and membrane permeability of Et3Pb+ in mammalian and plant cells. Cell biochemistry and function, 2(4), 213-216. doi:10.1002/cbf.290020406.

Cite as: https://hdl.handle.net/21.11116/0000-0006-8DD7-9

Abstract

Cells of mammalian origin as well as those of higher plants appear to be very sensitive to triethyllead ion (Et3Pb+). Neuroblastoma cells kept in the presence of 1 μM Et3Pb+ lost their viability within 6 h. Growth of suspension culture cells of soybean (G. max (L.)Merr.) was inhibited by 1 μM Et3Pb+, and finally the cells died. Morphologically, Et3Pb+ caused the complete breakdown of microtubular structures in neuroblastoma cells; thus microtubules appeared to be the main target for the toxin. While in a previous study the effect of Et3Pb+ on microtubules has been well documented at concentrations of 50–200 μM 1, the present study demonstrates that the formation of microtubules from pig brain tubulin is disturbed at concentrations of Et3Pb+ as low as 0.5 to 1 μM . We conclude from these data that Et3Pb+ freely permeates the plasma membranes of mammalian as well as plant cells.