Progress towards artificial hydrolases: synthesis and binding properties of a 
water-soluble cyclophane host with a phenol cap

Schürmann, G.; Diederich, Francois Nico

doi:10.1016/S0040-4039(00)94244-8

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Progress towards artificial hydrolases: synthesis and binding properties of a water-soluble cyclophane host with a phenol cap

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Schürmann, G.
Max Planck Institute for Medical Research, Max Planck Society;

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Diederich, Francois Nico
Max Planck Institute for Medical Research, Max Planck Society;

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https://www.sciencedirect.com/science/article/pii/S0040403900942448/pdf?md5=8c53678ceab2ef367ecfeb5570e76367&pid=1-s2.0-S0040403900942448-main.pdf
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Citation

Schürmann, G., & Diederich, F. N. (1986). Progress towards artificial hydrolases: synthesis and binding properties of a water-soluble cyclophane host with a phenol cap. Tetrahedron Letters, 27(36), 4249-4252. doi:10.1016/S0040-4039(00)94244-8.

Cite as: https://hdl.handle.net/21.11116/0000-0006-93C4-6

Abstract

The synthesis of the functionalized macrobicyclic host1 on the way to the water-soluble artificial esterase 2 is presented. A phenolic nucleophile is properly oriented atop the binding cavity of1 which forms strong complexes with aromatic guests in aqueous solutions.
Graphical Abstract

The synthesis of the macrobicyclic host1 on the way to the water-soluble artificial esterase2 is described. Host1 has a phenolic nucleophile atop the binding cavity and complexes aromatic guests in aqueous solution.