Simple synthesis and separation of the diastereomers of α-thio analogs of ribo- 
and deoxyribo- di- and triphosphates

Goody, Roger S.; Isakov, Maria

doi:10.1016/S0040-4039(00)84859-5

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Simple synthesis and separation of the diastereomers of α-thio analogs of ribo- and deoxyribo- di- and triphosphates

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Goody, Roger S.
Abt. III: Physikalische Biochemie, Max Planck Institute of Molecular Physiology, Max Planck Society;

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Isakov, Maria
Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Goody, R. S., & Isakov, M. (1986). Simple synthesis and separation of the diastereomers of α-thio analogs of ribo- and deoxyribo- di- and triphosphates. Tetrahedron Letters, 27(31), 3599-3602. doi:10.1016/S0040-4039(00)84859-5.

Cite as: https://hdl.handle.net/21.11116/0000-0006-9818-4

Abstract

Nucleoside 5′-0-(1-thiodi-) and triphosphates can be obtained in yields of up to 45% directly from the nucleosides. Their diastereomers can be separated by preparative reversed phase chromatography.