Encapsulated DNase improving the killing efficiency of antibiotics in 
staphylococcal biofilms

Liu, Chenhui; Zhao, Yu; Su, Wanqi; Chai, Jingshan; Xu, Lina; Cao, Jingjing; Liu, Yang

doi:10.1039/D0TB00441C

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Encapsulated DNase improving the killing efficiency of antibiotics in staphylococcal biofilms

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Su, Wanqi
Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Liu, C., Zhao, Y., Su, W., Chai, J., Xu, L., Cao, J., et al. (2020). Encapsulated DNase improving the killing efficiency of antibiotics in staphylococcal biofilms. Journal of Materials Chemistry B, 8(20), 4395-4401. doi:10.1039/D0TB00441C.

Cite as: https://hdl.handle.net/21.11116/0000-0006-AC0E-A

Abstract

We developed a polymer-encapsulated DNase, n(DNase), which can efficiently accumulate in biofilm and expose the DNase to cleave the eDNA of the biofilm. CLSM and crystal violet staining results demonstrated effective biofilm disintegration (92.2%) when treated with n(DNase). This work demonstrated a general approach for coating matrix-dispersion enzymes to achieve biofilm disintegration and provided a promising strategy for treating biofilm-associated infections.