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Metabolons, Enzyme-Enzyme Assemblies that Mediate Substrate Channeling, and Their Roles in Plant Metabolism

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Zhang,  YJ
Central Metabolism, Department Willmitzer, Max Planck Institute of Molecular Plant Physiology, Max Planck Society;

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Fernie,  A. R.
Central Metabolism, Department Willmitzer, Max Planck Institute of Molecular Plant Physiology, Max Planck Society;

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Citation

Zhang, Y., & Fernie, A. R. (2021). Metabolons, Enzyme-Enzyme Assemblies that Mediate Substrate Channeling, and Their Roles in Plant Metabolism. Plant Communications, 2: 100081. doi:10.1016/j.xplc.2020.100081.


Cite as: http://hdl.handle.net/21.11116/0000-0007-AADD-1
Abstract
Metabolons are a specific type of transient multi-protein complex of sequential enzymes which mediate substrate channeling. They differ from multi-enzyme complexes in that they are dynamic rather than permanent and as such have considerably lower dissociation constants. Despite the fact that a huge number of metabolons have been claimed to exist in plants most of these claims are erroneous since only a handful of these have been proven to channel metabolites. We believe that physical protein- protein interactions between consecutive enzymes of a pathway should rather be called enzyme-enzyme assemblies. In this review we describe how metabolons are generally assembled by transient interaction and held together both by structural elements and non-covalent interactions. Experimental evidence for their existence comes from protein-protein interaction studies