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Journal Article

Present-Day DNA Contamination in Ancient DNA Datasets


Prüfer,  Kay
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Peyrégne, S., & Prüfer, K. (2020). Present-Day DNA Contamination in Ancient DNA Datasets. Bioessays, 42(9): 2000081. doi:10.1002/bies.202000081.

Cite as: https://hdl.handle.net/21.11116/0000-0006-BBDC-0
Abstract Present-day contamination can lead to false conclusions in ancient DNA studies. A number of methods are available to estimate contamination, which use a variety of signals and are appropriate for different types of data. Here an overview of currently available methods highlighting their strengths and weaknesses is provided, and a classification based on the signals used to estimate contamination is proposed. This overview aims at enabling researchers to choose the most appropriate methods for their dataset. Based on this classification, potential avenues for the further development of methods are discussed.