English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

The Impact of Leaving Group Anomericity on the Structure of Glycosyl Cations of Protected Galactosides

MPS-Authors
/persons/resource/persons239542

Greis,  Kim
Institute of Chemistry and Biochemistry, Freie Universität Berlin ;
Molecular Physics, Fritz Haber Institute, Max Planck Society;

/persons/resource/persons183295

Mucha,  Eike
Molecular Physics, Fritz Haber Institute, Max Planck Society;

/persons/resource/persons221551

Lettow,  Maike
Institute of Chemistry and Biochemistry, Freie Universität Berlin ;
Molecular Physics, Fritz Haber Institute, Max Planck Society;

/persons/resource/persons203721

Thomas,  Daniel
Molecular Physics, Fritz Haber Institute, Max Planck Society;

/persons/resource/persons241114

Kirschbaum,  Carla
Institute of Chemistry and Biochemistry, Freie Universität Berlin ;
Molecular Physics, Fritz Haber Institute, Max Planck Society;

/persons/resource/persons21614

Helden,  Gert von
Molecular Physics, Fritz Haber Institute, Max Planck Society;

/persons/resource/persons21859

Meijer,  Gerard
Molecular Physics, Fritz Haber Institute, Max Planck Society;

/persons/resource/persons32738

Pagel,  Kevin
Institute of Chemistry and Biochemistry, Freie Universität Berlin ;
Molecular Physics, Fritz Haber Institute, Max Planck Society;

External Resource
No external resources are shared
Fulltext (public)

cphc.202000473.pdf
(Publisher version), 987KB

Supplementary Material (public)
There is no public supplementary material available
Citation

Greis, K., Mucha, E., Lettow, M., Thomas, D., Kirschbaum, C., Moon, S., et al. (2020). The Impact of Leaving Group Anomericity on the Structure of Glycosyl Cations of Protected Galactosides. ChemPhysChem, 21(17), 1905-1907. doi:10.1002/cphc.202000473.


Cite as: http://hdl.handle.net/21.11116/0000-0006-BCF0-7
Abstract
It has been reported that fragments produced by glycosidic bond breakage in mass spectrometry‐based experiments can retain a memory of their anomeric configuration, which has major implications for glycan sequencing. Here we use cryogenic vibrational spectroscopy and ion mobility‐mass spectrometry to study the structure of B‐type fragments of protected galactosides. Cationic fragments were generated from glycosyl donors carrying trichloroacetimidate or thioethyl leaving groups of different anomeric configuration. The obtained infrared signatures indicate that the investigated fragments exhibit an identical structure, which suggests that there is no anomeric memory in B‐type ions of fully protected monosaccharides.