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Meeting Abstract

Distinguish hemodynamic responses at the white matter tract from the laminar-specific gray matter fMRI signal with line-scanning fMRI

MPG-Autoren
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Choi,  S
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Zeng,  H
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Yu,  X
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

Externe Ressourcen

https://www.ismrm.org/20/program_files/O73.htm
(Zusammenfassung)

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Zitation

Choi, S., Zeng, H., Biswal, B., Rosen, B., & Yu, X. (2020). Distinguish hemodynamic responses at the white matter tract from the laminar-specific gray matter fMRI signal with line-scanning fMRI. In 2020 ISMRM & SMRT Virtual Conference & Exhibition.


Zitierlink: https://hdl.handle.net/21.11116/0000-0006-D7BD-3
Zusammenfassung
We applied line-scanning fMRI to investigate evoked hemodynamic responses in both laminar-specific gray matter (GM) and white matter (WM) in rats. Based on the WM-specific cross-correlation lag time to the laminar-specific fMRI signal, distinct WM hemodynamic responses were characterized across animals, showing a biphasic HRF with earlier lag times and a monophasic HRF with later lag times. Also, the lag-time dependent HRFs were detected in the subcortical area under the WM. Elucidating neurovascular coupling characteristics of distinct WM hemodynamic responses may help understand the progression of WM-related diseases, e.g. multiple sclerosis (MS) or small vessel disease (SVD).