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Deciphering the contribution of extracellular glutamate and intracellular calcium signaling to the BOLD fMRI signal

MPS-Authors
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Chen,  X
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Pais Roldán,  P
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons133486

Yu,  X
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Jiang, Y., Chen, X., Pais Roldán, P., Rosen, B., & Yu, X. (2020). Deciphering the contribution of extracellular glutamate and intracellular calcium signaling to the BOLD fMRI signal. In 2020 ISMRM & SMRT Virtual Conference & Exhibition (pp. 492).


Cite as: http://hdl.handle.net/21.11116/0000-0006-D7BF-1
Abstract
We established a multi-modal fMRI platform with two-channel fiber optic recording based on a genetically encoded fluorescent reporter, iGluSnFR, for extracellular glutamate (Glu) sensing and intracellular calcium indicator, GCaMP6f. Different from the intracellular neuronal and astrocytic calcium transients, the Glu signal, peak responses of spikes and baseline drift, show unique correlation features to the BOLD fMRI signal. Here, we applied the multi-modal fMRI platform to decipher the cellular and molecular interaction underlying the BOLD fMRI signal through the neuro-glio-vascular network in animal brains.