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Influence of formalin-based fixatives on the MR properties of whole post-mortem pig brains

MPS-Authors
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Nazemorroaya,  A
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons192852

Aghaeifar,  A
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons192862

Schulz,  H
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84187

Scheffler,  K
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons83952

Hagberg,  G
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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https://cds.ismrm.org/protected/20MProceedings/PDFfiles/4711.html
(Abstract)

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Citation

Nazemorroaya, A., Aghaeifar, A., Schulz, H., Shiozawa-Bayer, T., Hirt, B., Scheffler, K., et al. (2020). Influence of formalin-based fixatives on the MR properties of whole post-mortem pig brains. Poster presented at 2020 ISMRM & SMRT Virtual Conference & Exhibition.


Cite as: https://hdl.handle.net/21.11116/0000-0006-D882-3
Abstract
Post-mortem brain MRI can yield valuable information. However, tissue preservation and MR-compatibility of fixation agents are challenging. Here we investigated the effect of four MR-compatible formalin-based fixatives on the MR properties of pig brains at several timepoints after start of fixation up to one month. The inclusion agents known to improve the dielectric properties of the fixatives lead to greater R2* difference between GM-WM than conventional fixatives. Vice versa these agents lead to a decrease in T1 contrast.