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Snapshot whole brain CEST MRI at 3T with 3D-EPI

MPS-Authors
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Mueller,  S
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Scheffler,  K
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Zaiss,  M
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Mueller, S., Stirnberg, R., Akbey, S., Ehses, P., Scheffler, K., Stöcker, T., et al. (2020). Snapshot whole brain CEST MRI at 3T with 3D-EPI. Poster presented at 2020 ISMRM & SMRT Virtual Conference & Exhibition.


Cite as: http://hdl.handle.net/21.11116/0000-0006-D8B2-D
Abstract
CEST MRI provides metabolite-based contrasts but often suffers from poor volume coverage or spatial resolution. We optimized and included a snapshot 3D-EPI readout and propose a suitable post-processing pipeline to generate CEST contrast in the whole brain at clinical B0=3T. It is shown that CEST MRI with 1.8mm isotropic nominal resolution at a field of view of 256x224x156mm³ is feasible within 4.3s per presaturation frequency offset. The approach is adaptable for any presaturation scheme. Exemplarily low power saturation was performed and fitted Lorentzian amplitudes gave a coefficient of variation <8.5% across three healthy subjects.