English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

A whole-brain connectivity map of mouse insular cortex

MPS-Authors
/persons/resource/persons247230

Gehrlach,  Daniel A.
Max Planck Research Group: Circuits for Emotion / Gogolla, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons77986

Gaitanos,  Thomas N.
Max Planck Research Group: Circuits for Emotion / Gogolla, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons247228

Klein,  Alexandra S.
Max Planck Research Group: Circuits for Emotion / Gogolla, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons250033

Weiand,  Caroline
Max Planck Research Group: Circuits for Emotion / Gogolla, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons146123

Gogolla,  Nadine
Max Planck Research Group: Circuits for Emotion / Gogolla, MPI of Neurobiology, Max Planck Society;

External Ressource
No external resources are shared
Fulltext (public)

elife-55585-v2.pdf
(Publisher version), 5MB

Supplementary Material (public)
There is no public supplementary material available
Citation

Gehrlach, D. A., Gaitanos, T. N., Klein, A. S., Weiand, C., Hennrich, A. A., Conzelmann, K.-K., et al. (2020). A whole-brain connectivity map of mouse insular cortex. eLife, 9: e55585. doi:10.1101/2020.02.10.941518.


Cite as: http://hdl.handle.net/21.11116/0000-0006-DCD2-5
Abstract
The insular cortex (IC) plays key roles in emotional and regulatory brain functions and is affected across psychiatric diseases. However, the brain-wide connections of the mouse IC have not been comprehensively mapped. Here we traced the whole-brain inputs and outputs of the mouse IC across its rostro-caudal extent. We employed cell-type specific monosynaptic rabies virus tracings to characterize afferent connections onto either excitatory or inhibitory IC neurons, and adeno-associated viral tracings to label excitatory efferent axons. While the connectivity between the IC and other cortical regions was highly reciprocal, the IC connectivity with subcortical structures was often unidirectional, revealing prominent top-down and bottom-up pathways. The posterior and medial IC exhibited resembling connectivity patterns, while the anterior IC connectivity was distinct, suggesting two major functional compartments. Our results provide insights into the anatomical architecture of the mouse IC and thus a structural basis to guide investigations into its complex functions.