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Cryo-EM structure of the ribosome functional complex of the human pathogen Staphylococcus aureus at 3.2 Å resolution

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Khusainov,  Iskander
Laboratory of Structural Biology, Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russian Federation;
Department of Molecular Sociology, Max Planck Institute of Biophysics, Max Planck Society;

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Citation

Golubev, A., Fatkhullin, B., Khusainov, I., Jenner, L., Gabdulkhakov, A., Validov, S., et al. (2020). Cryo-EM structure of the ribosome functional complex of the human pathogen Staphylococcus aureus at 3.2 Å resolution. FEBS Letters, 594(21), 3551-3567. doi:10.1002/1873-3468.13915.


Cite as: https://hdl.handle.net/21.11116/0000-0006-ED8D-1
Abstract
Staphylococcus aureus is a bacterial pathogen and one of the leading causes of healthcare-acquired infections in the world. The growing antibiotic resistance of S. aureus obliges us to search for new drugs and treatments. As the majority of antibiotics target the ribosome, knowledge of its detailed structure is crucial for drug development. Here, we report the Cryo-EM reconstruction at 3.2 Å resolution of the S. aureus ribosome with P-site tRNA, messenger RNA and ten RNA modification sites previously not assigned or visualized. The resulting model is the most precise and complete high-resolution structure to date of the S. aureus 70S ribosome with functional ligands.