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Journal Article

MOSGA: Modular open-source genome annotator

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Martin, R., Hackl, T., Hattab, G., Fischer, M. G., & Heider, D. (2020). MOSGA: Modular open-source genome annotator. Bioinformatics, 36(22-23), 5514-5515. doi:10.1093/bioinformatics/btaa1003.

Cite as: https://hdl.handle.net/21.11116/0000-0006-FED4-D
Motivation: The generation of high-quality assemblies, even for large eukaryotic genomes, has become a routine task for many biologists thanks to recent advances in sequencing technologies. However, the annotation of these assemblies-a crucial step towards unlocking the biology of the organism of interest-has remained a complex challenge that often requires advanced bioinformatics expertise.

Results: Here we present MOSGA, a genome annotation framework for eukaryotic genomes with a user-friendly web-interface that generates and integrates annotations from various tools. The aggregated results can be analyzed with a fully integrated genome browser and are provided in a format ready for submission to NCBI. MOSGA is built on a portable, customizable, and easily extendible Snakemake backend, and thus, can be tailored to a wide range of users and projects.

Availability: We provide MOSGA as a web service at https://mosga.mathematik.uni-marburg.de and as a docker container at registry.gitlab.com/mosga/mosga: latest. Source code can be found at https://gitlab.com/mosga/mosga.