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Journal Article

The emergence of genome architecture and zygotic genome activation


Tachibana,  Kikuë
Tachibana, Kikuë / Totipotency, Max Planck Institute of Biochemistry, Max Planck Society;

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Vallot, A., & Tachibana, K. (2020). The emergence of genome architecture and zygotic genome activation. Current Opinion in Cell Biology, 64, 50-57. doi:10.1016/j.ceb.2020.02.002.

Cite as: https://hdl.handle.net/21.11116/0000-0007-332E-D
The fusion of two transcriptionally silent gametes, egg and sperm, generates a totipotent zygote that activates zygotic transcription to support further development. Although the molecular details of zygotic genome activation (ZGA) are not well understood in most species, an emerging concept is that one or more pioneer transcription factors trigger zygotic transcription. Concomitantly, extensive changes in 3D chromatin organization occur during development. In this review, we discuss recent advances in understanding when and how genome architecture emerges in early metazoan embryos, how the zygotic genome is activated, and how these events might be coordinated. We also highlight some of the unknowns that may be critical to address in the future.