English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Investigating the Structure of Neurotoxic Protein Aggregates Inside Cells.

MPS-Authors
/persons/resource/persons77699

Bäuerlein,  Felix J. B.
Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society;

/persons/resource/persons77952

Fernandez-Busnadiego,  Ruben
Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society;

/persons/resource/persons77721

Baumeister,  Wolfgang
Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society;

External Ressource
No external resources are shared
Fulltext (public)

1-s2.0-S0962892420301677-main.pdf
(Publisher version), 5MB

Supplementary Material (public)

1-s2.0-S0962892420301677-mmc1.docx
(Supplementary material), 44KB

Citation

Bäuerlein, F. J. B., Fernandez-Busnadiego, R., & Baumeister, W. (2020). Investigating the Structure of Neurotoxic Protein Aggregates Inside Cells. Trends in Cell Biology, 30(12), 951-966. doi:10.1016/j.tcb.2020.08.007.


Cite as: http://hdl.handle.net/21.11116/0000-0007-8CF1-B
Abstract
Neurodegenerative diseases affect the lives of millions of people across the world, being particularly prevalent in the aging population. Despite huge research efforts, conclusive insights into the disease mechanisms are still lacking. Therefore, therapeutic strategies are limited to symptomatic treatments. A common histopathological hallmark of many neurodegenerative diseases is the presence of large pathognomonic protein aggregates, but their role in the disease pathology is unclear and subject to controversy. Here, we discuss imaging methods allowing investigation of these structures within their cellular environment: conventional electron microscopy (EM), super-resolution light microscopy (SR-LM), and cryo-electron tomography (cryo-ET). Multidisciplinary approaches are key for understanding neurodegenerative diseases and may contribute to the development of effective treatments. For simplicity, we focus on huntingtin aggregates, characteristic of Huntington's disease. Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.